Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	3550
interventional	3109
Observational	414
Registry	27

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Behavioral	990
Drug	576
Drug\|placebo	517
Device	272
Other	259
Behavioral\|Other	114
Behavioral\|Drug	67
Procedure	44
Dietary Supplement\|placebo	23
Dietary Supplement	22
Drug\|Procedure	22
Drug\|Other	20
Behavioral\|Drug\|placebo	15
Behavioral\|placebo	13
Behavioral\|Device	12
Behavioral\|Other\|Procedure	10
Device\|Other	10
Device\|Drug\|placebo	8
Other\|Procedure	8
Behavioral\|Drug\|Other	7
Device\|Drug	7
Biological	6
Drug\|Other\|placebo	6
Dietary Supplement\|Drug	5
Genetic	5
Behavioral\|Drug\|Procedure	4
Biological\|placebo	4
Other\|placebo	4
Behavioral\|Device\|Other	3
Behavioral\|Procedure	3
Device\|placebo	3
Device\|Procedure	3
Dietary Supplement\|Drug\|placebo	3
Dietary Supplement\|Other	3
placebo\|Procedure	3
Behavioral\|Device\|Drug	2
Behavioral\|Dietary Supplement\|placebo	2
Combination Product	2
Combination Product\|placebo	2
Diagnostic Test\|Other	2
Drug\|placebo\|Procedure	2
Genetic\|Other	2
placebo	2
Behavioral\|Biological	1
Behavioral\|Biological\|Diagnostic Test\|Other	1
Behavioral\|Device\|placebo	1
Behavioral\|Diagnostic Test	1
Behavioral\|Diagnostic Test\|Other	1
Biological\|Device	1
Biological\|Device\|Other	1
Biological\|Dietary Supplement\|placebo	1
Biological\|Drug	1
Combination Product\|Device	1
Combination Product\|Drug\|Other	1
Combination Product\|Other	1
Device\|Diagnostic Test\|Drug\|Other	1
Device\|Drug\|Other\|placebo	1
Device\|Other\|placebo	1
Device\|Other\|Radiation	1
Diagnostic Test	1
Diagnostic Test\|Drug	1
Dietary Supplement\|Drug\|Other	1
Drug\|Genetic	1
Drug\|Other\|Procedure	1
Drug\|Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	1574
Canada	203
NA	193
Germany	89
China	75
United Kingdom	64
France	54
Sweden	48
Denmark	40
Japan	40
Brazil	37
Spain	37
Australia	31
Hong Kong	31
Norway	30
Korea, Republic of	29
Taiwan	28
Israel	25
Netherlands	22
Pakistan	22
United States\|Canada	20
Switzerland	16
United States\|Puerto Rico	16
Belgium	14
India	13
Italy	13
Turkey	13
Finland	10
Ireland	10
Poland	9
Austria	8
Chile	8
Egypt	7
Mexico	7
Singapore	7
Iran, Islamic Republic of	5
Romania	5
South Africa	5
Uganda	5
Colombia	4
United States\|Australia	4
Germany\|Switzerland	3
Kenya	3
Malawi	3
Malaysia	3
Russian Federation	3
United States\|China	3
Vietnam	3
Croatia	2
Germany\|Netherlands	2
Japan\|Korea, Republic of	2
Japan\|Taiwan	2
Philippines	2
Portugal	2
United States\|Canada\|Germany\|Israel	2
United States\|India	2
United States\|Israel	2
United States\|Mexico	2
Argentina	1
Argentina\|Belgium\|Chile\|Costa Rica\|Germany\|Italy\|Peru\|Poland\|Slovakia\|Spain\|Sweden	1
Argentina\|Brazil\|Bulgaria\|Chile\|Colombia\|Croatia\|France\|Germany\|Hungary\|Poland\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Ukraine	1
Argentina\|Brazil\|Chile\|Colombia\|Guatemala\|Mexico\|Peru\|Turkey\|Venezuela	1
Argentina\|Bulgaria\|Canada\|Chile\|Croatia\|Mexico\|Russian Federation	1
Argentina\|Bulgaria\|Croatia\|Czech Republic\|Finland\|France\|Mexico\|Poland\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa	1
Argentina\|Chile\|Greece\|Hong Kong\|Morocco\|Russian Federation\|Singapore\|South Africa\|Spain\|Taiwan\|Tunisia	1
Australia\|Austria\|Belgium\|Canada\|Czech Republic\|Finland\|France\|India\|Korea, Republic of\|Lithuania\|Malaysia\|Norway\|Philippines\|Russian Federation\|Serbia\|Sweden\|Ukraine	1
Australia\|Belgium\|Bulgaria\|Canada\|Estonia\|Finland\|France\|Germany\|India\|Poland\|Slovakia\|South Africa	1
Australia\|Belgium\|Canada\|Czech Republic\|Finland\|France\|Germany\|Norway\|Poland\|Romania\|South Africa\|Sweden	1
Australia\|Belgium\|Finland\|Netherlands\|Norway\|Russian Federation	1
Australia\|Canada\|Mexico\|Russian Federation\|Taiwan	1
Australia\|Czech Republic\|France\|Germany\|Korea, Republic of\|Latvia\|Lithuania\|Malaysia\|Netherlands\|Poland\|Russian Federation\|South Africa\|Taiwan\|Ukraine\|United Kingdom	1
Australia\|Japan\|Korea, Republic of\|Malaysia\|Taiwan	1
Australia\|Singapore	1
Australia\|Turkey	1
Austria\|Croatia\|France\|Hungary\|Poland\|Romania\|Russian Federation\|Serbia\|Ukraine\|United Kingdom	1
Austria\|Czech Republic\|Germany	1
Austria\|Czech Republic\|Italy\|Romania\|Slovakia\|Spain	1
Austria\|Finland\|France\|Germany\|Italy\|Netherlands\|Norway\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|Ukraine	1
Austria\|Germany	1
Bangladesh	1
Belgium\|Czech Republic\|Finland\|France\|Germany\|Slovakia	1
Belgium\|Estonia\|Finland\|France\|Germany\|Greece\|India\|Korea, Republic of\|Malaysia\|Morocco\|Taiwan\|Tunisia\|Turkey	1
Belgium\|Germany\|Netherlands	1
Belgium\|Germany\|Poland	1
Bolivia	1
Brazil\|Bulgaria\|Chile\|Czechia\|Germany\|Hungary\|Japan\|Mexico\|Poland\|Russian Federation\|Slovakia\|South Africa	1
Brazil\|United States\|Belgium\|Canada\|Estonia\|France\|Hungary\|Mexico\|Slovakia	1
Bulgaria\|Canada\|Chile\|Costa Rica\|Croatia\|France\|Germany\|India\|Italy\|Poland	1
Bulgaria\|Croatia\|Former Serbia and Montenegro\|Romania	1
Bulgaria\|Croatia\|Romania\|Serbia	1
Bulgaria\|Czechia\|Finland\|Hungary\|Russian Federation\|Slovakia\|Ukraine	1
Bulgaria\|Estonia\|France\|Germany\|Hungary\|Italy\|Latvia\|Poland\|Russian Federation\|Serbia\|South Africa\|Spain\|United Kingdom	1
Bulgaria\|Estonia\|Latvia	1
Bulgaria\|Finland\|Romania\|Serbia\|Slovakia	1
Bulgaria\|Hungary\|Moldova, Republic of\|Romania\|Russian Federation\|Ukraine	1
Canada\|Chile\|Croatia\|Czech Republic\|France\|Germany\|Mexico\|Portugal	1
Canada\|Chile\|Croatia\|Czechia\|Estonia\|Germany\|Mexico\|Portugal	1
Canada\|Croatia\|Estonia\|Germany\|Indonesia\|Korea, Republic of\|Latvia\|Lithuania\|Malaysia\|Norway\|Philippines\|Poland\|Russian Federation\|Serbia\|Taiwan\|Ukraine	1
Chile\|Mexico\|Romania\|Russian Federation\|Slovakia\|South Africa\|Ukraine	1
China\|Hong Kong	1
Costa Rica	1
Croatia\|Estonia\|Finland\|France\|Latvia\|Lithuania\|Poland\|Romania\|Slovakia\|South Africa	1
Cuba	1
Czech Republic\|Estonia\|Finland\|France\|Germany\|Hungary\|Latvia\|Lithuania\|Poland\|Sweden	1
Denmark\|France\|Greece\|Hungary\|Italy\|Netherlands\|Romania\|Slovenia\|Spain\|Sweden\|Turkey	1
Denmark\|Iceland\|Italy\|Poland\|Spain	1
Estonia\|Finland	1
Estonia\|Finland\|Germany\|Lithuania	1
Estonia\|Finland\|Germany\|Serbia\|Slovakia	1
Estonia\|France\|Italy\|Korea, Republic of\|Poland\|Spain	1
Estonia\|Russian Federation	1
Estonia\|United States\|Belgium\|Czechia\|Finland\|Germany\|Hungary\|Poland\|Romania\|South Africa\|Sweden	1
Finland\|Germany\|Poland\|Bulgaria\|United States\|Russian Federation\|Ukraine	1
Finland\|Germany\|Serbia\|Slovakia	1
Finland\|Poland\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Ukraine\|United Kingdom	1
Finland\|Sweden	1
France\|Germany\|Netherlands\|Spain\|United Kingdom	1
France\|Israel\|United Kingdom	1
France\|Italy\|Lithuania\|Spain	1
France\|Monaco	1
Germany\|Netherlands\|Spain\|United Kingdom	1
Guatemala	1
Haiti	1
Hungary	1
Iceland	1
India\|China\|Korea, Republic of\|Taiwan	1
Indonesia	1
Iraq	1
Italy\|Australia\|Austria\|Belgium\|Bulgaria\|Denmark\|Germany\|Hungary\|Portugal\|Romania\|Slovakia\|Spain\|United Kingdom	1
Italy\|Poland	1
Japan\|	1
Japan\|Lithuania\|Malaysia\|Philippines\|Russian Federation\|Slovakia\|Taiwan\|Ukraine	1
Japan\|United States	1
Japan\|United States\|Bulgaria\|Poland\|Russian Federation\|Serbia\|Slovakia\|Ukraine	1
Kosovo	1
Lebanon	1
Mexico\|Canada\|China\|Finland\|Korea, Republic of\|Malaysia\|Philippines\|South Africa\|Spain	1
Moldova, Republic of\|Romania	1
Nepal	1
Netherlands\|Spain	1
Netherlands\|Switzerland	1
Peru	1
Poland\|Spain\|United States\|Czechia\|Germany	1
Poland\|United States\|Belgium\|Brazil\|Bulgaria\|Finland\|France\|Lithuania\|South Africa\|Spain\|Sweden\|United Kingdom	1
Puerto Rico	1
Russian Federation\|Austria	1
Russian Federation\|United States\|Austria\|Canada\|Germany\|Slovakia\|South Africa\|Ukraine	1
Rwanda	1
Serbia\|United States\|Bulgaria\|Canada\|Colombia\|Estonia\|France\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Latvia\|Mexico\|Poland\|Russian Federation\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Serbia\|United States\|Canada\|France\|Germany\|Poland\|Russian Federation	1
Serbia\|United States\|Russian Federation\|Ukraine\|United Kingdom	1
Spain\|Sweden\|United Kingdom	1
Spain\|United States\|Belgium\|Brazil\|Canada\|Czechia\|Estonia\|France\|Germany\|Hungary\|Mexico\|Poland\|Slovakia\|Sweden\|Turkey	1
Tanzania	1
Thailand	1
Ukraine	1
Ukraine\|Croatia\|Finland\|Germany\|Hong Kong\|India\|Japan\|Korea, Republic of\|Latvia\|Malaysia\|Philippines\|Poland\|Romania\|Russian Federation\|Serbia\|Taiwan	1
United Kingdom\|United States\|Moldova, Republic of\|Russian Federation\|Spain\|Ukraine	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|Czechia\|Estonia\|Finland\|France\|Germany\|Hungary\|Italy\|Korea, Republic of\|Lithuania\|Malaysia\|Mexico\|Poland\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Finland\|France\|Germany\|Korea, Republic of\|Lithuania\|Malaysia\|Mexico\|Poland\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Canada\|France\|India\|Italy\|Puerto Rico\|South Africa\|Spain\|United Kingdom	1
United States\|Argentina\|Australia\|Bulgaria\|Canada\|France\|Poland\|South Africa\|Spain\|Ukraine	1
United States\|Argentina\|Australia\|Chile\|United Kingdom	1
United States\|Argentina\|Austria\|Belgium\|Brazil\|Canada\|Czechia\|France\|Lithuania\|Poland\|Spain\|Turkey	1
United States\|Argentina\|Belgium\|Brazil\|Bulgaria\|Germany\|Spain	1
United States\|Argentina\|Belgium\|Croatia\|France\|Germany\|Greece\|Italy\|Korea, Republic of\|Mexico\|Puerto Rico\|Romania\|Russian Federation\|Slovakia\|Spain\|Turkey	1
United States\|Argentina\|Brazil\|Bulgaria\|Croatia\|Finland\|Germany\|Hungary\|Italy\|Poland\|Serbia\|Slovakia\|South Africa\|Ukraine	1
United States\|Argentina\|Canada\|Mexico	1
United States\|Argentina\|Chile\|Colombia\|Mexico\|Peru	1
United States\|Argentina\|Estonia\|Finland\|Russian Federation\|Ukraine	1
United States\|Argentina\|Finland\|France\|Mexico\|Sweden	1
United States\|Argentina\|Finland\|Poland\|Russian Federation	1
United States\|Argentina\|India\|Mexico\|Puerto Rico\|Russian Federation\|South Africa\|Turkey	1
United States\|Australia\|Austria\|Belgium\|Germany\|Sweden\|United Kingdom	1
United States\|Australia\|Bulgaria\|Canada\|Germany\|Hungary\|Poland\|Puerto Rico	1
United States\|Australia\|Canada	1
United States\|Australia\|Canada\|France\|Korea, Republic of\|United Kingdom	1
United States\|Australia\|Chile\|Colombia\|Costa Rica\|Greece\|Mexico\|Peru\|Romania\|South Africa\|Turkey	1
United States\|Australia\|Croatia\|France\|Germany\|Korea, Republic of\|Latvia\|Lithuania\|Malaysia\|Netherlands\|Poland\|Russian Federation\|Serbia\|South Africa\|Taiwan\|Ukraine\|United Kingdom	1
United States\|Australia\|India	1
United States\|Australia\|Netherlands\|New Zealand\|South Africa	1
United States\|Australia\|Puerto Rico	1
United States\|Belgium\|Brazil\|Bulgaria\|France\|Hungary\|Italy\|Poland\|Spain	1
United States\|Belgium\|Germany\|Netherlands\|United Kingdom	1
United States\|Belgium\|Japan	1
United States\|Bosnia and Herzegovina\|Croatia\|Germany\|Hungary\|Romania\|Russian Federation\|Spain	1
United States\|Brazil\|Chile\|Lithuania\|Mexico\|Netherlands\|Spain	1
United States\|Bulgaria	1
United States\|Bulgaria\|Canada\|Colombia\|Estonia\|France\|Germany\|Hungary\|Israel\|Italy\|Korea, Republic of\|Latvia\|Mexico\|Poland\|Russian Federation\|Serbia\|South Africa\|Spain\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Canada\|Colombia\|Estonia\|France\|Germany\|Hungary\|Italy\|Korea, Republic of\|Latvia\|Mexico\|Poland\|Russian Federation\|Serbia\|South Africa\|Spain\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Canada\|Colombia\|Russian Federation\|Ukraine	1
United States\|Bulgaria\|Canada\|Estonia\|Finland\|Germany\|Korea, Republic of\|Latvia\|Lithuania\|Mexico\|Poland\|Romania\|Russian Federation\|Sweden\|Ukraine\|United Kingdom	1
United States\|Bulgaria\|Canada\|Puerto Rico\|Romania\|Russian Federation\|Slovakia\|United Kingdom	1
United States\|Bulgaria\|Colombia\|France\|Hungary\|Korea, Republic of\|Mexico\|Philippines\|Poland\|Puerto Rico\|Ukraine	1
United States\|Bulgaria\|Colombia\|Russian Federation\|Serbia\|Ukraine	1
United States\|Bulgaria\|Croatia\|Puerto Rico\|Romania\|Serbia\|Slovakia\|Ukraine	1
United States\|Bulgaria\|Estonia\|Germany\|Hungary\|Korea, Republic of\|Malaysia\|Slovakia\|South Africa\|Spain\|Taiwan	1
United States\|Bulgaria\|Estonia\|Germany\|Hungary\|Ukraine	1
United States\|Bulgaria\|Estonia\|Germany\|Russian Federation	1
United States\|Bulgaria\|Estonia\|Lithuania\|Poland\|Puerto Rico	1
United States\|Bulgaria\|Finland\|France\|Germany\|Japan\|Russian Federation\|Ukraine	1
United States\|Bulgaria\|Finland\|Germany\|Romania\|Russian Federation\|Serbia\|Ukraine	1
United States\|Bulgaria\|Finland\|Poland	1
United States\|Bulgaria\|Hungary\|Romania	1
United States\|Bulgaria\|Russian Federation\|Serbia\|Ukraine	1
United States\|Canada\|Chile\|Colombia\|Croatia\|Estonia\|Finland\|France\|Latvia\|Lithuania\|Poland\|Romania\|Slovakia\|South Africa	1
United States\|Canada\|Colombia\|Czech Republic\|France\|India\|Japan\|Lithuania\|Peru\|Poland\|Romania\|Russian Federation\|Slovakia\|South Africa\|Ukraine	1
United States\|Canada\|Colombia\|Czech Republic\|India\|Japan\|Lithuania\|Peru\|Slovakia\|Ukraine	1
United States\|Canada\|Croatia\|Mexico\|Puerto Rico\|Spain	1
United States\|Canada\|Czechia\|Denmark\|Ireland\|Netherlands\|Portugal\|Spain\|United Kingdom	1
United States\|Canada\|Finland\|France\|South Africa\|Sweden	1
United States\|Canada\|France\|Germany\|Hungary\|Poland\|Romania\|Russian Federation\|Serbia\|Slovakia\|Ukraine	1
United States\|Canada\|France\|Germany\|Israel	1
United States\|Canada\|France\|Italy\|Spain	1
United States\|Canada\|France\|Poland\|Slovakia	1
United States\|Canada\|Germany\|Hungary\|Romania\|Russian Federation\|Ukraine	1
United States\|Canada\|Germany\|Puerto Rico	1
United States\|Canada\|Israel	1
United States\|Canada\|Italy\|Spain	1
United States\|Canada\|Mexico	1
United States\|Canada\|Poland\|Russian Federation\|United Kingdom	1
United States\|Canada\|Puerto Rico	1
United States\|Chile	1
United States\|Chile\|Estonia\|Germany\|Korea, Republic of\|Mexico\|Russian Federation\|South Africa	1
United States\|Chile\|Estonia\|Russian Federation	1
United States\|Chile\|Germany\|Japan\|Mexico\|Poland\|Romania\|Russian Federation\|Taiwan	1
United States\|Chile\|Mexico	1
United States\|Chile\|Slovakia\|South Africa	1
United States\|Colombia\|India\|Mexico\|Serbia\|South Africa\|Taiwan	1
United States\|Croatia\|Czech Republic\|France\|Mexico\|Russian Federation\|Sweden\|Turkey	1
United States\|Croatia\|Czechia\|Finland\|Japan\|Puerto Rico\|Slovakia	1
United States\|Czech Republic\|France\|Germany\|India\|Poland\|Romania\|Russian Federation\|South Africa\|Ukraine	1
United States\|Czech Republic\|France\|India\|Romania\|Russian Federation\|South Africa\|Ukraine	1
United States\|Czechia\|Finland\|Germany\|Greece\|Israel\|Poland\|Russian Federation\|Spain	1
United States\|Czechia\|Finland\|Poland\|Puerto Rico\|Slovakia	1
United States\|Estonia\|Finland\|Former Serbia and Montenegro\|France\|Germany\|Latvia\|Lithuania\|Poland\|Slovakia\|South Africa	1
United States\|Estonia\|Finland\|Slovakia\|Sweden\|Ukraine	1
United States\|Finland\|Poland\|Russian Federation\|Serbia\|Slovakia\|Ukraine\|United Kingdom	1
United States\|France\|Germany\|Italy\|Russian Federation\|Sweden	1
United States\|France\|Germany\|Japan\|Netherlands\|Singapore\|Spain	1
United States\|France\|Germany\|Puerto Rico\|Romania\|Sweden	1
United States\|France\|Germany\|Russian Federation\|Slovakia\|South Africa\|Ukraine	1
United States\|Germany	1
United States\|Germany\|Hungary\|Poland\|Slovakia	1
United States\|Germany\|Moldova, Republic of\|Russian Federation\|Ukraine\|United Kingdom	1
United States\|India\|Puerto Rico	1
United States\|Italy	1
United States\|Japan\|Latvia\|Poland\|Russian Federation\|South Africa\|Ukraine	1
United States\|Kenya\|Tanzania	1
United States\|Russian Federation	1
United States\|South Africa	1
United States\|Spain	1
United States\|Taiwan	1
Zambia	1
Zimbabwe	1

Sites per Study

Site_count	Study_Count
1	2177
2	273
3	86
4	73
5	29
6	35
7	20
8	22
9	18
10	10
11	8
12	12
13	11
14	10
15	10
16	9
17	7
18	7
19	6
20	6
21	8
22	8
23	6
24	7
25	10
26	5
27	5
28	2
29	3
30	2
31	5
32	10
33	4
34	6
35	6
36	4
37	8
38	6
39	2
40	5
41	3
42	3
43	9
44	7
45	5
46	3
47	7
48	3
49	3
50	5
51	5
52	2
53	4
54	3
55	4
56	5
57	2
58	3
59	2
60	2
61	5
62	3
63	3
65	1
66	4
67	1
68	1
69	2
70	4
71	4
72	2
73	3
74	4
75	2
76	4
77	2
78	3
79	2
82	1
83	1
84	1
85	3
87	2
88	1
89	2
90	1
91	1
92	4
93	1
94	1
99	1
101	2
106	1
107	1
110	1
117	1
124	1
128	1
130	1
136	1
137	1
144	1
149	1
151	1
158	1
160	1
168	1
363	1

Phase

Phase	Study_Count
N/A	1695
Phase 3	395
Phase 4	361
Phase 2	340
Phase 1	150
Phase 2/Phase 3	79
Phase 1/Phase 2	53
Early Phase 1	36

Number of Arms

Number_of_Arms	Count_of_Studies
1	461
2	1800
3	376
4	151
5	22
6	12
7	6
8	5
9	1
10	2
11	1
13	1
14	1
16	1
NA	269

Number of Updates

Count of Versions	Count of Studies
1	299
2	399
3	408
4	325
5	312
6	269
7	192
8	189
9	123
10	85
11	84
12	68
13	53
14	39
15	23
16	34
17	20
18	15
19	8
20	7
21	11
22	8
23	12
24	4
25	4
26	8
27	10
28	5
29	8
30	9
31	13
32	2
33	5
34	2
35	3
36	3
37	7
38	1
39	5
40	4
41	3
42	2
43	1
45	2
46	1
47	1
48	1
51	1
53	1
56	1
57	1
59	1
61	1
62	2
64	1
66	1
71	1
75	1
77	2
85	1
100	1
110	1
116	1
151	1
162	1
168	1
182	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	19064	2810	6.784342
Contacts/Locations	8529	2404	3.547837
Recruitment Status	4427	2462	1.798132
Study Design	3294	2138	1.540692
None (earliest Version on record)	3109	3109	1.000000
Outcome Measures	2617	1561	1.676489
Sponsor/Collaborators	2167	1382	1.568017
Arms	1930	1223	1.578087
Interventions	1930	1223	1.578087
Study Identification	1867	1171	1.594364
Eligibility	1859	1147	1.620750
Study Description	1834	1102	1.664247
Oversight	1133	919	1.232862
References	899	572	1.571678
Conditions	645	440	1.465909
Results	619	619	1.000000
More Information	470	297	1.582492
IPDSharing	361	340	1.061765
Results Submission Events	210	210	1.000000
Baseline Characteristics	157	139	1.129496
Documents	150	132	1.136364
Reported Adverse Events	116	109	1.064220
Participant Flow	96	89	1.078652
2020 Study Status	1	1	1.000000
Quality Control Review has not concludedReturned: June 11	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	2	2.000	3.0000	4.0000	3.0000	8.0000	2.0000	2.0000
1st Qu.	17	43.000	20.0000	20.0000	35.0000	55.0000	139.0000	36.5000
Median	32	90.000	36.0000	40.0000	74.0000	90.0000	328.5000	86.0000
Mean	86	265.896	129.2381	191.8679	148.7151	186.7342	404.1333	202.2584
3rd Qu.	78	200.000	71.0000	74.0000	174.0000	256.0000	534.7500	206.2500
Max.	1247	25871.000	8231.0000	5000.0000	1197.0000	1326.0000	3000.0000	4000.0000

Trial Group Type

group_type	Group_Count
Experimental	3131
Active Comparator	1355
Placebo Comparator	749
No Intervention	507
NA	269
Other	258
Sham Comparator	140

Intervention Model

intervention_model	Study_Count
Parallel Assignment	2236
Single Group Assignment	569
Crossover Assignment	155
Factorial Assignment	87
NA	43
Sequential Assignment	19

Primary Purpose

primary_purpose	Study_Count
Treatment	2276
Prevention	271
Health Services Research	125
Supportive Care	125
Basic Science	105
Other	98
NA	47
Diagnostic	33
Screening	21
Device Feasibility	6
Educational/Counseling/Training	2

Observational Studies

Studies by Country

Country	Study_Count
United States	183
NA	39
Canada	18
France	14
Germany	14
United Kingdom	14
Norway	13
Spain	12
Denmark	10
Turkey	9
China	7
Israel	6
Singapore	5
Taiwan	5
Thailand	5
Austria	4
Korea, Republic of	4
Belgium	3
Brazil	3
Greece	3
India	3
Italy	3
Poland	3
Japan	2
Netherlands	2
Pakistan	2
Russian Federation	2
Switzerland	2
Argentina	1
Austria\|China\|Hong Kong\|Israel\|Lebanon\|Malaysia\|Mexico\|Philippines\|Saudi Arabia\|Singapore\|Taiwan\|Thailand\|United Arab Emirates	1
Austria\|France\|Germany\|Italy\|Netherlands\|Spain\|Switzerland\|United Kingdom	1
Chile	1
China\|Hong Kong	1
Congo, The Democratic Republic of the	1
Denmark\|Netherlands\|Sweden	1
Egypt	1
Finland	1
Hong Kong	1
Indonesia	1
Iran, Islamic Republic of	1
Malawi	1
Malaysia	1
Mexico	1
Portugal	1
Puerto Rico	1
South Africa	1
Sweden	1
Trinidad and Tobago	1
United States\|Albania\|Australia\|Czechia\|France\|Germany\|Hong Kong\|Israel\|Italy\|Lebanon\|Norway\|Poland\|Spain\|Sweden\|Taiwan	1
United States\|Canada\|France\|Italy	1
United States\|Singapore	1
United States\|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	328
2	30
3	11
4	6
5	6
6	2
7	1
8	1
10	4
14	1
15	2
16	1
17	2
20	1
22	1
23	1
24	2
25	1
27	1
29	2
34	1
47	1
48	1
55	1
57	2
72	1
91	1
106	1
238	1

Number of Updates

Count of Versions	Count of Studies
1	47
2	86
3	48
4	53
5	39
6	27
7	26
8	12
9	11
10	3
11	4
12	4
13	4
14	7
15	1
17	5
18	2
20	3
21	3
22	1
23	2
25	1
26	1
28	2
31	2
33	1
34	1
38	1
45	1
48	1
49	1
52	1
54	1
55	1
60	1
62	2
81	1
97	1
106	1
112	1
143	1
159	1
167	1
181	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	3293	367	8.972752
Contacts/Locations	809	281	2.879004
Study Description	717	142	5.049296
Study Design	474	258	1.837209
Recruitment Status	471	288	1.635417
None (earliest Version on record)	414	414	1.000000
Eligibility	358	173	2.069364
Sponsor/Collaborators	228	150	1.520000
Outcome Measures	207	137	1.510949
Study Identification	195	134	1.455224
References	188	74	2.540541
Groups	138	99	1.393939
Interventions	138	99	1.393939
Oversight	131	114	1.149123
Conditions	100	64	1.562500
IPDSharing	30	28	1.071429
Results	27	27	1.000000
More Information	14	8	1.750000
Results Submission Events	8	8	1.000000
Documents	6	6	1.000000
Baseline Characteristics	5	5	1.000000
Participant Flow	3	3	1.000000
Reported Adverse Events	3	2	1.500000

Enrollment Metrics

Measure	Observational
Min	4.000
1st Qu	70.750
Median	158.000
Mean	1906.865
3rd Qu	543.500
Max	186394.000

Observation Model

observational_model	Study_Count
Cohort	197
NA	54
Case-Control	45
Case-Only	44
Case Control	31
Other	22
Ecologic or Community	8
Defined Population	5
Case-Crossover	3
Defined Population, Natural History	2
Family-Based	2
Natural History	1

Time Perspective

time_perspective	Study_Count
Prospective	254
Cross-Sectional	78
Retrospective	34
NA	32
Other	8
Cross-Sectional, Prospective	4
Cross-Sectional, Retrospective	3
Longitudinal, Retrospective/Prospective	1

Registries

Studies by Country

Country	Study_Count
United States	5
China	4
NA	4
Canada	3
Turkey	2
Argentina	1
Austria\|Belgium\|Germany\|United Kingdom	1
Belgium	1
Denmark	1
France	1
Israel	1
Poland	1
Taiwan	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	23
2	1
8	1
12	1
16	1

Number of Updates

Count of Versions	Count of Studies
1	9
2	4
3	4
4	4
5	3
7	1
12	1
13	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	65	18	3.611111
Contacts/Locations	28	13	2.153846
None (earliest Version on record)	27	27	1.000000
Recruitment Status	14	12	1.166667
Outcome Measures	13	10	1.300000
Study Design	10	10	1.000000
Eligibility	5	4	1.250000
Oversight	5	5	1.000000
Study Identification	4	4	1.000000
Groups	3	2	1.500000
Interventions	3	2	1.500000
Sponsor/Collaborators	3	2	1.500000
Study Description	3	2	1.500000
Conditions	2	2	1.000000
IPDSharing	1	1	1.000000
References	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	20.000
1st Qu	87.000
Median	300.000
Mean	1832.037
3rd Qu	802.500
Max	30000.000

Registry Model

observational_model	Study_Count
Cohort	24
Case-Control	2
Family-Based	1

Time Perspective

time_perspective	Study_Count
Prospective	23
Cross-Sectional	3
Other	1

Follow-up

target_duration	Study_Count
1 Year	3
6 Months	3
1 Month	2
1 Week	2
10 Years	2
12 Months	2
12 Weeks	2
3 Years	2
5 Years	2
2 Weeks	1
2 Years	1
24 Months	1
3 Months	1
6 Weeks	1
7 Days	1
9 Months	1

intervention_type	Study_Count
Behavioral	990
Drug	576
Drug\|placebo	517
Device	272
Other	259
Behavioral\|Other	114
Behavioral\|Drug	67
Procedure	44
Dietary Supplement\|placebo	23
Dietary Supplement	22
Drug\|Procedure	22
Drug\|Other	20
Behavioral\|Drug\|placebo	15
Behavioral\|placebo	13
Behavioral\|Device	12
Behavioral\|Other\|Procedure	10
Device\|Other	10
Device\|Drug\|placebo	8
Other\|Procedure	8
Behavioral\|Drug\|Other	7
Device\|Drug	7
Biological	6
Drug\|Other\|placebo	6
Dietary Supplement\|Drug	5
Genetic	5
Behavioral\|Drug\|Procedure	4
Biological\|placebo	4
Other\|placebo	4
Behavioral\|Device\|Other	3
Behavioral\|Procedure	3
Device\|placebo	3
Device\|Procedure	3
Dietary Supplement\|Drug\|placebo	3
Dietary Supplement\|Other	3
placebo\|Procedure	3
Behavioral\|Device\|Drug	2
Behavioral\|Dietary Supplement\|placebo	2
Combination Product	2
Combination Product\|placebo	2
Diagnostic Test\|Other	2
Drug\|placebo\|Procedure	2
Genetic\|Other	2
placebo	2
Behavioral\|Biological	1
Behavioral\|Biological\|Diagnostic Test\|Other	1
Behavioral\|Device\|placebo	1
Behavioral\|Diagnostic Test	1
Behavioral\|Diagnostic Test\|Other	1
Biological\|Device	1
Biological\|Device\|Other	1
Biological\|Dietary Supplement\|placebo	1
Biological\|Drug	1
Combination Product\|Device	1
Combination Product\|Drug\|Other	1
Combination Product\|Other	1
Device\|Diagnostic Test\|Drug\|Other	1
Device\|Drug\|Other\|placebo	1
Device\|Other\|placebo	1
Device\|Other\|Radiation	1
Diagnostic Test	1
Diagnostic Test\|Drug	1
Dietary Supplement\|Drug\|Other	1
Drug\|Genetic	1
Drug\|Other\|Procedure	1
Drug\|Radiation	1

Count of Versions	Count of Studies
1	299
2	399
3	408
4	325
5	312
6	269
7	192
8	189
9	123
10	85
11	84
12	68
13	53
14	39
15	23
16	34
17	20
18	15
19	8
20	7
21	11
22	8
23	12
24	4
25	4
26	8
27	10
28	5
29	8
30	9
31	13
32	2
33	5
34	2
35	3
36	3
37	7
38	1
39	5
40	4
41	3
42	2
43	1
45	2
46	1
47	1
48	1
51	1
53	1
56	1
57	1
59	1
61	1
62	2
64	1
66	1
71	1
75	1
77	2
85	1
100	1
110	1
116	1
151	1
162	1
168	1
182	1

Site_count	Study_Count
1	328
2	30
3	11
4	6
5	6
6	2
7	1
8	1
10	4
14	1
15	2
16	1
17	2
20	1
22	1
23	1
24	2
25	1
27	1
29	2
34	1
47	1
48	1
55	1
57	2
72	1
91	1
106	1
238	1

Count of Versions	Count of Studies
1	47
2	86
3	48
4	53
5	39
6	27
7	26
8	12
9	11
10	3
11	4
12	4
13	4
14	7
15	1
17	5
18	2
20	3
21	3
22	1
23	2
25	1
26	1
28	2
31	2
33	1
34	1
38	1
45	1
48	1
49	1
52	1
54	1
55	1
60	1
62	2
81	1
97	1
106	1
112	1
143	1
159	1
167	1
181	1

Count of Versions	Count of Studies
1	299
2	399
3	408
4	325
5	312
6	269
7	192
8	189
9	123
10	85
11	84
12	68
13	53
14	39
15	23
16	34
17	20
18	15
19	8
20	7
21	11
22	8
23	12
24	4
25	4
26	8
27	10
28	5
29	8
30	9
31	13
32	2
33	5
34	2
35	3
36	3
37	7
38	1
39	5
40	4
41	3
42	2
43	1
45	2
46	1
47	1
48	1
51	1
53	1
56	1
57	1
59	1
61	1
62	2
64	1
66	1
71	1
75	1
77	2
85	1
100	1
110	1
116	1
151	1
162	1
168	1
182	1

Site_count	Study_Count
1	328
2	30
3	11
4	6
5	6
6	2
7	1
8	1
10	4
14	1
15	2
16	1
17	2
20	1
22	1
23	1
24	2
25	1
27	1
29	2
34	1
47	1
48	1
55	1
57	2
72	1
91	1
106	1
238	1

Count of Versions	Count of Studies
1	47
2	86
3	48
4	53
5	39
6	27
7	26
8	12
9	11
10	3
11	4
12	4
13	4
14	7
15	1
17	5
18	2
20	3
21	3
22	1
23	2
25	1
26	1
28	2
31	2
33	1
34	1
38	1
45	1
48	1
49	1
52	1
54	1
55	1
60	1
62	2
81	1
97	1
106	1
112	1
143	1
159	1
167	1
181	1

depression

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Count of Versions	Count of Studies
1	299
2	399
3	408
4	325
5	312
6	269
7	192
8	189
9	123
10	85
11	84
12	68
13	53
14	39
15	23
16	34
17	20
18	15
19	8
20	7
21	11
22	8
23	12
24	4
25	4
26	8
27	10
28	5
29	8
30	9
31	13
32	2
33	5
34	2
35	3
36	3
37	7
38	1
39	5
40	4
41	3
42	2
43	1
45	2
46	1
47	1
48	1
51	1
53	1
56	1
57	1
59	1
61	1
62	2
64	1
66	1
71	1
75	1
77	2
85	1
100	1
110	1
116	1
151	1
162	1
168	1
182	1

Site_count	Study_Count
1	328
2	30
3	11
4	6
5	6
6	2
7	1
8	1
10	4
14	1
15	2
16	1
17	2
20	1
22	1
23	1
24	2
25	1
27	1
29	2
34	1
47	1
48	1
55	1
57	2
72	1
91	1
106	1
238	1

Count of Versions	Count of Studies
1	47
2	86
3	48
4	53
5	39
6	27
7	26
8	12
9	11
10	3
11	4
12	4
13	4
14	7
15	1
17	5
18	2
20	3
21	3
22	1
23	2
25	1
26	1
28	2
31	2
33	1
34	1
38	1
45	1
48	1
49	1
52	1
54	1
55	1
60	1
62	2
81	1
97	1
106	1
112	1
143	1
159	1
167	1
181	1